Current Research Projects
Supporting research in head and neck cancer, and the sharing of knowledge.
Current Research Projects
Supporting research in head and neck cancer, and the sharing of knowledge.
Member information on Current Research Projects being undertaken by our Members
Investigators: M Abdul-Razak, H Chung, E Wong, C Palme, M Veness, D Farlow, H Coleman and Gary Morgan
Information provided by ANZHNCS Member: Dr Muzib Abdul-Razak, Westmead Hospital
Funded by the Garnett Passe and Rodney Williams Memorial Foundation
Investigators: EH Ooi, D Hussey, CM Woods, NH Dharmawardana
Information provided by ANZHNCS Member: A/Prof Eng H. Ooi, Flinders University
Funded by the ANZHNCS foundation
Investigators: EH Ooi, R Yazbek, CM Woods, NH Dharmawardana
Information provided by ANZHNCS Member: A/Prof Eng H. Ooi, Flinders University
Funded by the GPRWMF academic surgeon scientist research scholarship program
Investigators: N. Dharmawardana, R. Yazbeck, E.H. Ooi.
Information provided by ANZHNCS Member: A/Prof Eng H. Ooi, Flinders University
Partly funded by the Faculty of Health Sciences seeding grant, Flinders University
Investigators: Mistyka Schar, C.M. Woods, T. Omari, T. Athanasiadis, C. Cock, E.H. Ooi
Information provided by ANZHNCS Member: A/Prof Eng H. Ooi, Flinders University
Investigators: Jae Park, Anna Megow, Adam Swalling, Sam Boase, S. Kao, JC Hodge, Suren Krishnan, E.H. Ooi
Information provided by ANZHNCS Member: A/Prof Eng H. Ooi, Flinders University
Funding applied for.
Investigators: Jane Bickford, Sebastian Doeltgen, C.M. Woods, E.H. Ooi
Information provided by ANZHNCS Member: A/Prof Eng H. Ooi, Flinders University
Chief Investigator: Courtenay Henrys, Year 3 MBBS. BAppSci (Human Movement Studies)
Research Supervisor: Dr Roger Grigg MBBS FRACS
Contact Person (ie. Dept Secretary etc.): Dr Roger Grigg
Information provided by ANZHNCS Member: Dr Roger Grigg
Chief Investigator: Courtenay Henrys, Year 3 MBBS. BAppSci (Human Movement Studies)
Research Supervisor: Dr Roger Grigg MBBS FRACS
Contact Person (ie. Dept Secretary etc.): Dr Roger Grigg
Information provided by ANZHNCS Member: Dr Roger Grigg
Chief Investigator
Research Supervisor: Dr Roger Grigg MBBS FRACS
Contact Person (ie. Dept Secretary etc.): Dr Roger Grigg
Information provided by ANZHNCS Member: Dr Roger Grigg
Chief Investigator: Sarah Deacon, Townsville Hospital
Contact Person (ie. Dept Secretary etc.: Sarah Deacon, Townsville Hospital
Email: Sarah.Deacon@health.qld.gov.au
Information provided by ANZHNCS Member: Sarah Deacon
Titles:
- N. Beech, M. Batstone, S. Porceddu – the impact of preradiotherapy dental extractions on the development of osteoradionecrosis and quality of life
- M. Batstone, O. Ellis – Frozen sections and their influence on surgical margins in oral cavity cancer
- Gore S, Clark J, Batstone M, Crombie A – chemoradiotherapyvs surgery and adjuvant xrt for the management of oral cavity cancer
- M. Batstone – comparative analysis of jejunal free flap and tubed fasciocutaneous flaps for pharyngolaryngectomy defects
- Farah C, Batstone M + others – narrow band imaging and molecular margin analysis in head and neck
- Batstone M, Subramaniam S, Sharp D – the cost effectiveness of free flap monitoring
Chief Investigators
- Nick Beech nicholasbeech@gmail.com
- Martin Batstone martin.batstone@health.qld.gov.au
- Jonathon Clarke jcjc@tpg.co
- Martin BAtstone martin.batstone@health.qld.gov.au
- Camile Farah c.farah@uq.edu.au
- Shiva Subramaniam shivasubramaniam@gmail.com
Contact Person (ie. Dept Secretary etc.:
Ms Pauline Haley (07) 3646 7681
Email: pauline.haley@health.qld.gov.au
Information provided by ANZHNCS Member: Dr Martin Batstone
Titles:
- 1.HPV in oropharynx
- Epidemiology of H&N Cancers
- Identification of molecular and immuno diagnostic cancer markers in Northern Territory population
Chief Investigator: Dr Mahiban Thomas
Contact Person (ie. Dept Secretary etc.): Dr Mahiban Thomas
Information provided by ANZHNCS Member: Dr Mahiban Thomas, Darwin Hospital
Chief Investigator: Dr Iain Ward
Contact Person (ie. Dept Secretary etc.): Dr Iain Ward
Information provided by ANZHNCS Member: Dr Iain Ward, The Canterbury Regional Cancer and Haematology Service
Titles:
- Sample Saliva Test to Diagnose Head and Neck Cancer at an Early Stage – with Chamindie Punyadeera
- Defining the role of HPV in causation of Oral Cavity Cancers in Non-Smokers
Chief Investigator: Dr Chris Perry
Contact Person (ie. Dept Secretary etc.): Dr Chris Perry
Information provided by ANZHNCS Member: Dr Chris Perry, Brisbane ENT
Titles:
a) Further studies regarding biomarkers for non- smoking, non-drinking patients who develop oral squamous cell carcinomas. PhD project
S. Belobrov, D. Wiesenfeld, M. McCullough,
b) Oral yeasts’ carriage and biofilm forming ability and exfoliative cytology in oral cancer patients. PhD project
A. Al Nuami, D. Wiesenfeld, M.McCullough
c) Molecular Oncogenesis of Oral Cavity and Oropharyngeal Squamous Cell Carcinoma PhD Project
K Koo,T Iseli, D Wiesenfeld, A Burgess
d) A role for panendoscopy? Second primary tumours in early stage squamous cell carcinoma of the oral tongue
K Koo, R Harris, D Wiesenfeld, T Iseli
Chief Investigators: Dr Tim Iseli, Michael McCullough
Contact Person (ie. Dept Secretary etc.): Dr Tim Iseli, Michael McCullough
Information provided by ANZHNCS Member: Dr Tim Iseli, Michael McCullough, Dr David Wiesenfeld, Royal Melbourne Hospital
Supervisor: Dr. Richard Lewis Email: drlewis@ohns.com.au
Chief Investigator: Dr. Jae Park Email: parja731@yahoo.com
Contact Person (ie. Dept Secretary etc.): Dr. Jae Park; Dr. Richard Lewis
Information provided by ANZHNCS Member: Dr Richard Lewis, Perth WA
Translational Research Activities
Cancer Biology
1. Individualising care in head and neck cancer using genetic markers of cancer progression to guide drug target selection in a mouse model
2. Tissue microarray analysis of oropharyngeal SCC tumour specimens
3. Defining the role of HPV in the causation of oral cavity cancers in non-smokers / Viral oncogenesis in oral squamous cell carcinoma.
4. Studying the factors involved in the perineural spread of cutaneous squamous cell carcinomas of the head and neck
5. Perineural spread of cutaneous malignancy in a live mouse model and ganglion tumour coculture model
6. Optimising intratumoural treatment of HNSCC mouse models with a novel drug EBC-46
7. The role of LoxL2 in perineural invasion of cutaneous squamous cell carcinoma
8. Studies on squamous carcinoma formation and the development of novel therapies
Rhinosinusitis
9. High throughput screening of bioactive extracts for anti-inflammatory properties and the development of an in-situ nasal gelling drug delivery system for the treatment of chronic rhinosinusitis
Imaging
10.Evaluation of accuracy of 3T MRI in evaluation of head and neck perineural invasion
Epidemiology
11. Head and Neck Cancer Study
Clinical Trials
12. Phase I dose-escalation study to determine the safety and tolerability of an intratumoural injection of EBC-46 in patients with refractory cutaneous or subcutaneous tumours
13. A pilot study of an old drug with a new use – prochlorperazine to improve anti-EGFR therapy in squamous cell carcinoma of the mucosa
14. Phase I/II open-label clinical trial of autologous EBV-specific T cell therapy as consolidative treatment following chemotherapy for metastatic EBV-associated NPC
Surgical Trial
15. Primary trans-oral surgical management of early tonsillar squamous cell carcinoma followed by risk-adapted radiotherapy
16. Drop Neck Study Assessment of need for neck dissection in cutaneous metastatic disease to the parotid:
Diagnostics
17. A simple saliva test to diagnose head and neck cancer at an early stage
18. A saliva-based method for the detection of HPV-associated oral cancers
19. Salivary glycoproteins as biomarkers for head and neck squamous cell carcinoma
20. To develop a method to detect circulating tumour cells (CTC’s) in metastatic head and neck squamous cell carcinoma
21. Identification of breath biomarkers from head and neck SCC
Information provided by Andrew Wetzig, Research Coordinator, Queensland Head and Neck Cancer Centre; ANZHNCS Member A/Prof Ben Panizza, PA Hospital, Brisbane, Qld
Professor Camile Farah, Perth, Western Australia
Research Project Titles:
- Genomic sequencing of head and neck cancers and precancers
- Exomic and transcriptomic profile of early onset oral cancers
- DNA damage repair pathways in oral leukoplakia
- Single cell sequencing of oral carcinoma and dysplasia
- Role of HPV in oral leukoplakia
- Predictive molecular signature of epithelial dysplasia
- Malignant transformation of oral potentially malignant disorders
- Optical fluorescence imaging of oral potentially malignant disorders
- Correlation of confocal laser endomicroscopy with histology
- Confocal laser endomicroscopy for head and neck cancer delineation
Chief Investigators: Professor Camile Farah, Dr Simon Fox, Dr Kate Shearston
Collaborators: Dr Chady Sader (Western ENT and St John of God Hospital), Dr Charbel Darido (Peter MacCallum Cancer Centre), Prof Alistair Forrest (Harry Perkins Institute of Medical Research), Dr Jenny Grew (Australian Clinical Labs), Dr Omar Kujan (UWA), Associate Professor Carol Tran (CQ University)
Contact Person (ie. Dept Secretary etc.): Professor Camile Farah
Information provided by ANZHNCS Member: Professor Camile Farah, Australian Centre for Oral Oncology Research & Education.